Francisco Rodriguez may refer to:
- Francisco Rodríguez (Venezuelan pitcher), Major League Baseball relief pitcher for the Milwaukee Brewers who is nicknamed "K-Rod"
- Francisco Rodríguez (Mexican pitcher), Major League Baseball pitcher for the Los Angeles Angels of Anaheim
- Francisco Rodríguez (boxer, born 1945), Venezuelan boxer
- Francisco Rodriguez (boxer, born 1984), American boxer
- Francisco Rodríguez (economist), Venezuelan economist
- Francisco Rodríguez (President of Panama)
- Francisco Javier Rodríguez, Mexican footballer
- Francisco Rodríguez García, Spanish footballer
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